The European Garden Flora 5 Volume ...
A Manual for the Identification ...
The European Garden Flora is the definitive manual for the accurate identification of cultivated ornamental flowering plants. Designed to meet the highest scientific standards, the vocabulary has nevertheless been kept as uncomplicated as possible so ...
2011, Cambridge University ...
Book, Quantity pack, 5 items/volumes
Electrochemical Technologies for ...
In this handbook and ready reference, editors and authors from academia and industry share their in-depth knowledge of known and novel materials, devices and technologies with the reader. The result is a comprehensive overview of electrochemical energy and conversion methods,...
2011, Wiley-VCH
Book, Hardback, 2 items/volumes
Classical and New Perspectives
The notion of subjectivity is one of the most fundamental notions for modern philosophy that only gains in importance in present-day discussions. This volume gathers essays from both young and senior researchers that examine which role subjectivity plays in both classical and contemporary phenomenology....
2011, Brill
Book, Hardback
Handbook of Computational Chemistry...
The role the Handbook of Computational Chemistry is threefold. It is primarily intended to be used as a guide that navigates the user through the plethora of computational methods currently in use; it explains their limitations and advantages; and it ...
2012, Springer Netherlands...
Book, Hardback, 3 items/volumes
Handbook of Climate Change Mitigation...
There is a mounting consensus that human behavior is changing the global climate and its consequence could be catastrophic. Reducing the 24 billion metric tons of carbon dioxide emissions from stationary and mobile sources is a gigantic task involving ...
2012, Springer, Berlin
Book, Hardback, 4 items/volumes
Shah, Pallav; Singh, Suveer
Atlas of Flexible Bronchoscopy
This unique and comprehensive atlas by an expert practioner provides an innovative pictorial guide to flexible bronchoscopy, one of the most exciting and challenging procedures in respiratory medicine today. *Includes the very latest procedures and techniques *Comprehensive coverage,...
2011, Hodder Education
Book, Hardback
The automation of visual inspection is becoming more and more important in modern industry as a consistent, reliable means of judging the quality of raw materials and manufactured goods and elsewhere for processes like security scanning and traffic enforcement....
2012, Springer, Berlin
Book, 3 items/volumes
The Post-War Occupation of Japan,...
Selected Contemporary Readings ...
This set presents a collection of book-length accounts of the post-war occupation of Japan. These view the Occupation as it progressed from varied American, Japanese and Allied perspectives, highlighting the diversity of policies and responses to a controversial and important era....
2011, Brill
Book, Hardback, 10 items/volumes
Anton, Michael
Allgemeiner Teil Des Internationalen ...
Der erste Teil vervollständigt zunächst die voranstehenden Bände um die in der Praxis des Kulturgüterschutzes und der Kunstrestitution bedeutsamen Mittel und Wege des Strafrechts aus nationaler wie internationaler Sicht und dessen Reaktionsmöglichkeiten auf den illegalen Kunsthandel,...
2011, de Gruyter
Book, Hardback
Froude, James Anthony
History of England from the Fall ...
James Anthony Froude (1818-94), historian and disciple of Carlyle, published this twelve-volume history of the English Reformation between 1858 and 1870. The work is shaped by Froude's firm belief that the Reformation enabled the development of modernity and the rise of 'progressive intelligence' in England....
2011, Cambridge Library ...
Book, Quantity pack, 12 items/volumes
From Basic Research to Cancer Therapy...
In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field.
The authors summarize knowledge gained over the past decade,...
2011, Wiley-VCH
Book, Hardback, 3 items/volumes
Models, Methods, and Applications
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Dorband, Bernd; Muller, Henriette;...
Handbook of Optical Systems: Metrology ...
Metrology of Optical Components ...
Herbert Gross, born in 1955, joined Carl Zeiss in 1982 after finishing his physics degree as specialist for optical design. Since 1995 he has been working as head of the department of optical design, while also teaching as a lecturer in Aalen and Lausanne. The new handbook is an intuitive,...
2012, Wiley-VCH
Book, Hardback
Ritzer, George
The Wiley-Blackwell Encyclopedia ...
This five-volume Encyclopedia contains over 600 entries on the essential topics of Globalization and is the definitive reference resource for students, researchers and academics in the field.
Offers clear and concise explanations of the key concepts of ...
2012, Wiley & Sons
Book, Hardback
Richardson, Samuel
'Aesop's Fables', 'letters Written ...
This is the first edition to assemble all of the earliest known works by Samuel Richardson (1689-1761), one of the most influential authors in the English tradition. Richardson's exercises in conduct-writing, religious controversialism, anti-theatrical polemic, occasional verse,...
2011, Cambridge University ...
Book, Hardback
The Wiley-Blackwell History of ...
Comprising over 90 essays and richly illustrated with over 200 images, the Wiley-Blackwell History of American Film provides a chronological portrait of American film history from its origins to the present day.
Taken as a whole, the essays in this collection ...
2011, Wiley & Sons
Book, Hardback, 4 items/volumes
Physiology of the Gastrointestinal ...
The gastrointestinal system is responsible for the breakdown and absorption of various foods and liquids needed to sustain life. Other diseases and disorders treated by clinicians in this area include: food allergies, constipation, chronic liver disease and cirrhosis, gallstones,...
2012, Elsevier Science ...
Book, Hardback, 2 items/volumes
Santos, Olga C.; Gonzalez Boticario,...
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Practices and Challenges
2012, Business Science ...
Book, Hardback
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Emerging Drugs and Targets for Alzheimer's Disease
Complete Set
EUR 265,90
GBP 220,00
USD 352,00
(non-binding price)
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Bibliographic data: Publisher: Royal Society of Chemistry published in: Cambridge, GB ISBN: 978-1-84973-045-7 Series: RSC Drug Discovery; v. 1 Pages: 668 Language: English (en) Size: Width [156 mm] Height [234 mm] Depth [51 mm] Weight: 1329 gram Product Type: Book Binding: Hardback, 2 items/volumes Publication Year: 2010 Last Update: 02/04/2012 08:02:54 |
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Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the elderly. The Bloomberg School of Public Health recently estimated that over 26 million people were living with AD in 2006 and that the number will grow to 106 million by 2050. Interventions that delay onset by just one year could reduce the 2050 figure by 12 million. This demonstrates the importance and social need of finding an effective therapeutic intervention. Both volumes gather together some of the most promising examples of drugs now in pharmaceutical development, and new targets currently going through a validation process. It describes the discovery and development history of the disease modifying therapeutics most likely to reach the Alzheimer's market in the next few years. It will be of interest to both those working in the pharmaceutical industry and in academia from graduate level onwards.
Table of Content VOLUME 1; Beta-Amyloid as target; Chapter 1: The amyloid hypothesis of AD and prospects for therapeutics; Chapter 2:Targeting Alzheimer's ?-Secretase: Genetic and Chemical Modulation; Chapter 3: Cholesterol and AD: the molecules, the targets; Chapter 4: The Bimodal Features of Butyrylcholinesterase in Cholinergic Neurotransmission and Amyloid Suppression; Chapter 5: Scyllo-inositol, a potential therapy for Alzheimer's disease; Chapter 6: Immunotherapeutic strategies toward treatment of AD; Tau protein as target; Chapter 7: Alzheimer Neurofibrillary Degeneration: Pivotal Role and Therapeutic Targets; Chapter 8: Multiple roles of glycogen synthase kinase-3 in AD; Chapter 9: Tau protein kinases inhibitors: from the bench to the clinical trials; Chapter 10: Activating PP2A as a therapeutic intervention strategy in AD; Chapter 11: Rationale for tau aggregation inhibitor therapy in Alzheimer's disease and other tauopathies; Glucose Metabolism as target; Chapter 12: Insulin Insulin Resistance and neurodegeneration: Type 2 versus type 3 diabetes mellitus; Chapter 13: Insulin-like Growth Factor I as a disease-modifying therapy in Alzheimer's disease; Chapter 14: Ketone bodies as a therapeutic for Alzheimer's disease; VOLUME 2; Neuronal Plasticity as target; Chapter 15: Regeneration of Degenerated Brain: A Promising Therapeutic Target; Chapter 16: Promoting synaptic resilience in AD patients through PDE inhibition; Chapter 17: A new generation of non invasive NGF-based therapies for Alzheimer's disease; Chapter 18: Possible clinical applications of stem cell strategies in AD therapies; Neuronal protection as target; Chapter 19: Targeting Oxidative Mechanisms in Alzheimer Disease; Chapter 20: Davunetide (NAP) Pharmacology: Neuroprotection and tau; Chapter 21: Targeting NF- B inflammatory and pro-survival signaling in AD; Chapter 22: PPAR in Alzheimer's disease; Miscellaneous targets and strategies; Chapter 23: Serotonin 5-HT4 receptors as pharmacological targets for the treatment of Alzheimer's disease; Chapter 24: Liver X Receptors as potential therapeutic target for AD; Chapter 25: Discovery of memoquin, a multi-target-directed ligand for the treatment of Alzheimer's disease; Chapter 26. RNA interference of genes related to AD; B. Nawrot; Chapter 27. Medicinal plants, phytochemicals and Alzheimer's Disease; D. Kennedy |
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